human NAE1 shRNA silencing AAV

Cat. No: shAAV-216285

Availability: 4-5 weeks

Name: AAV-h-NAE1-shRNA

This is an AAV expressing shRNA for silencing of Human NAE1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: NAE1
Gene Name: NEDD8 activating enzyme E1 subunit 1
Gene ID: 8883
Gene Synonyms: A-116A10.1; APPBP1; HPP1; ula-1
ORF Size: 1605 bp
RefSeq#: NM_003905
Gene Description: NAE1 binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene.
UniGene ID: Hs.460978
HGNC ID: HGNC:621