human MYOT shRNA silencing AAV

Cat. No: shAAV-216234

Availability: 6-8 weeks

Name: AAV-h-MYOT-shRNA

This is an AAV expressing shRNA for silencing of Human MYOT.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: MYOT
Gene Name: myotilin
Gene ID: 9499
Gene Synonyms: LGMD1; LGMD1A; MFM3; TTID; TTOD
ORF Size: 1497 bp
RefSeq#: NM_006790
Gene Description: MYOT encodes a cystoskeletal protein which plays a significant role in the stability of thin filaments during muscle contraction. This protein binds F-actin, crosslinks actin filaments, and prevents latrunculin A-induced filament disassembly. Mutations in this gene have been associated with limb-girdle muscular dystrophy and myofibrillar myopathies. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
UniGene ID: Hs.84665
HGNC ID: HGNC:12399