human MUC20 shRNA silencing AAV

Cat. No: shAAV-216072

Availability: 6-8 weeks

Name: AAV-h-MUC20-shRNA

This is an AAV expressing shRNA for silencing of Human MUC20.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: MUC20
Gene Name: mucin 20, cell surface associated
Gene ID: 200958
Gene Synonyms: MUC-20
ORF Size: 1668 bp
RefSeq#: NM_152673
Gene Description: MUC20 encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins secreted by many epithelial tissues to form an insoluble mucous barrier. The shorter isoform expressed by this gene is localized to the plasma membrane, whereas the longer isoform might be secreted. The C terminus of this protein associates with the multifunctional docking site of the met proto-oncogene and suppresses activation of some downstream met signaling cascades. The protein features a tandem repeat domain that varies between 2 and 6 copies in most individuals. The allele represented in the human reference assembly contains 12 copies. Multiple transcript variants encoding different isoforms have been found for this gene.
UniGene ID: Hs.308992
HGNC ID: HGNC:23282