human MTRR shRNA silencing AAV

Cat. No: shAAV-216052

Availability: 4-5 weeks

Name: AAV-h-MTRR-shRNA

This is an AAV expressing shRNA for silencing of Human MTRR.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: MTRR
Gene Name: 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
Gene ID: 4552
Gene Synonyms: cblE; MSR
ORF Size: 2097 bp
RefSeq#: NM_002454
Gene Description: Methionine is an essential amino acid required for protein synthesis and one-carbon metabolism. Its synthesis is catalyzed by the enzyme methionine synthase. Methionine synthase eventually becomes inactive due to the oxidation of its cob(I)alamin cofactor. The protein encoded by this gene regenerates a functional methionine synthase via reductive methylation. It is a member of the ferredoxin-NADP(+) reductase (FNR) family of electron transferases. Patients of the cbl-E complementation group of disorders of folate/cobalamin metabolism are defective in reductive activation of methionine synthase. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.
UniGene ID: Hs.481551
HGNC ID: HGNC:7473