human MTMR3 shRNA silencing AAV

Cat. No: shAAV-216019

Availability: 4-5 weeks

Name: AAV-h-MTMR3-shRNA

This is an AAV expressing shRNA for silencing of Human MTMR3.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: MTMR3
Gene Name: myotubularin related protein 3
Gene ID: 8897
Gene Synonyms: FYVE-DSP1; ZFYVE10
ORF Size: 3597 bp
RefSeq#: NM_021090
Gene Description: MTMR3 encodes a member of the myotubularin dual specificity protein phosphatase gene family. The encoded protein is structurally similar to myotubularin but in addition contains a FYVE domain and an N-terminal PH-GRAM domain. The protein can self-associate and also form heteromers with another myotubularin related protein. The protein binds to phosphoinositide lipids through the PH-GRAM domain, and can hydrolyze phosphatidylinositol(3)-phosphate and phosphatidylinositol(3,5)-biphosphate in vitro. The encoded protein has been observed to have a perinuclear, possibly membrane-bound, distribution in cells, but it has also been found free in the cytoplasm. Multiple transcript variants encoding different isoforms have been found for this gene.
UniGene ID: Hs.474536
HGNC ID: HGNC:7451