human MTAP shRNA silencing AAV

Cat. No: shAAV-215970

Availability: 4-5 weeks

Name: AAV-h-MTAP-shRNA

This is an AAV expressing shRNA for silencing of Human MTAP.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: MTAP
Gene Name: methylthioadenosine phosphorylase
Gene ID: 4507
Gene Synonyms: BDMF; c86fus; DMSFH; DMSMFH; HEL-249; LGMBF; MSAP
ORF Size: 729 bp
RefSeq#: NM_002451
Gene Description: MTAP encodes an enzyme that plays a major role in polyamine metabolism and is important for the salvage of both adenine and methionine. The encoded enzyme is deficient in many cancers because this gene and the tumor suppressor p16 gene are co-deleted. Multiple alternatively spliced transcript variants have been described for this gene, but their full-length natures remain unknown.
UniGene ID: Hs.193268
HGNC ID: HGNC:7413