human MPST shRNA silencing AAV

Cat. No: shAAV-215731

Availability: 4-5 weeks

Name: AAV-h-MPST-shRNA

This is an AAV expressing shRNA for silencing of Human MPST.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: MPST
Gene Name: mercaptopyruvate sulfurtransferase
Gene ID: 4357
Gene Synonyms: MST; TST2; TUM1
ORF Size: 894 bp
RefSeq#: NM_021126
Gene Description: This protein encoded by this gene catalyzes the transfer of a sulfur ion from 3-mercaptopyruvate to cyanide or other thiol compounds. It may be involved in cysteine degradation and cyanide detoxification. There is confusion in literature between this protein (mercaptopyruvate sulfurtransferase, MPST), which appears to be cytoplasmic, and thiosulfate sulfurtransferase (rhodanese, TST, GeneID:7263), which is a mitochondrial protein. Deficiency in MPST activity has been implicated in a rare inheritable disorder known as mercaptolactate-cysteine disulfiduria (MCDU). Alternatively spliced transcript variants encoding same or different isoforms have been identified for this gene.
UniGene ID: Hs.248267
HGNC ID: HGNC:7223