human MMP3 shRNA silencing AAV

Cat. No: shAAV-215596

Availability: 4-5 weeks

Name: AAV-h-MMP3-shRNA

This is an AAV expressing shRNA for silencing of Human MMP3.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: MMP3
Gene Name: matrix metallopeptidase 3
Gene ID: 4314
Gene Synonyms: CHDS6; MMP-3; SL-1; STMY; STMY1; STR1
ORF Size: 1434 bp
RefSeq#: NM_002422
Gene Description: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.
UniGene ID: Hs.375129
HGNC ID: HGNC:7173