human MMP13 shRNA silencing AAV

Cat. No: shAAV-215572

Availability: 6-8 weeks

Name: AAV-h-MMP13-shRNA

This is an AAV expressing shRNA for silencing of Human MMP13.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: MMP13
Gene Name: matrix metallopeptidase 13
Gene ID: 4322
Gene Synonyms: CLG3; MANDP1; MDST; MMP-13
ORF Size: 1416 bp
RefSeq#: NM_002427
Gene Description: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.
UniGene ID: Hs.2936
HGNC ID: HGNC:7159