human MKL1 shRNA silencing AAV

Cat. No: shAAV-215497

Availability: 4-5 weeks

Name: AAV-h-MKL1-shRNA

This is an AAV expressing shRNA for silencing of Human MKL1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: MKL1
Gene Name: megakaryoblastic leukemia (translocation) 1
Gene ID: 57591
Gene Synonyms: BSAC; MAL; MRTF-A
ORF Size: 2793 bp
RefSeq#: NM_020831
Gene Description: MKL1 interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia.
UniGene ID: Hs.654688
HGNC ID: HGNC:14334