human MITF shRNA silencing AAV

Cat. No: shAAV-215490

Availability: 4-5 weeks

Name: AAV-h-MITF-shRNA

This is an AAV expressing shRNA for silencing of Human MITF.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: MITF
Gene Name: melanogenesis associated transcription factor
Gene ID: 4286
Gene Synonyms: bHLHe32; CMM8; MI; WS2; WS2A
ORF Size: 1260 bp
RefSeq#: NM_000248
Gene Description: MITF encodes a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. It regulates the differentiation and development of melanocytes retinal pigment epithelium and is also responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.
UniGene ID: Hs.618266
HGNC ID: HGNC:7105