human MCOLN1 shRNA silencing AAV

Cat. No: shAAV-215197

Availability: Immediate

Name: AAV-h-MCOLN1-shRNA

This is an AAV expressing shRNA for silencing of Human MCOLN1.

Request a Quote

Please enter your email address and we'll be in touch with more information:

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: MCOLN1
Gene Name: mucolipin 1
Gene ID: 57192
Gene Synonyms: MG-2; ML4; MLIV; MST080; MSTP080; TRP-ML1; TRPM-L1; TRPML1
ORF Size: 1743 bp
RefSeq#: NM_020533
Gene Description: MCOLN1 encodes a memberof the transient receptor potential (TRP) cation channel gene family. The transmembrane protein localizes to intracellular vesicular membranes including lysosomes, and functions in the late endocytic pathway and in the regulation of lysosomal exocytosis. The channel is permeable to Ca(2+), Fe(2+), Na(+), K(+), and H(+), and is modulated by changes in Ca(2+) concentration. Mutations in this gene result in mucolipidosis type IV.
UniGene ID: Hs.631858
HGNC ID: HGNC:13356