human MBNL2 shRNA silencing AAV

Cat. No: shAAV-215107

Availability: 4-5 weeks

Name: AAV-h-MBNL2-shRNA

This is an AAV expressing shRNA for silencing of Human MBNL2.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: MBNL2
Gene Name: muscleblind like splicing regulator 2
Gene ID: 10150
Gene Synonyms: MBLL; MBLL39; PRO2032
ORF Size: 1086 bp
RefSeq#: NM_207304
Gene Description: MBNL2 is a member of the muscleblind protein family which was initially described in Drosophila melanogaster. MBNL2 encodes a C3H-type zinc finger protein that modulates alternative splicing of pre-mRNAs. Muscleblind proteins bind specifically to expanded dsCUG RNA but not to normal size CUG repeats and may thereby play a role in the pathophysiology of myotonic dystrophy. Several alternatively spliced transcript variants have been described but the full-length natures of only some have been determined.
UniGene ID: Hs.657347
HGNC ID: HGNC:16746