human MAP3K7 shRNA silencing AAV

Cat. No: shAAV-214938

Availability: 4-5 weeks

Name: AAV-h-MAP3K7-shRNA

This is an AAV expressing shRNA for silencing of Human MAP3K7.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: MAP3K7
Gene Name: mitogen-activated protein kinase kinase kinase 7
Gene ID: 6885
Gene Synonyms: CSCF; FMD2; MEKK7; TAK1; TGF1a
ORF Size: 1740 bp
RefSeq#: NM_145332
Gene Description: MAP3K7 is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
UniGene ID: Hs.644143
HGNC ID: HGNC:6859