human MAP2K2 shRNA silencing AAV

Cat. No: shAAV-214915

Availability: 4-5 weeks

Name: AAV-h-MAP2K2-shRNA

This is an AAV expressing shRNA for silencing of Human MAP2K2.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: MAP2K2
Gene Name: mitogen-activated protein kinase kinase 2
Gene ID: 5605
Gene Synonyms: CFC4; MAPKK2; MEK2; MKK2; PRKMK2
ORF Size: 1203 bp
RefSeq#: NM_030662
Gene Description: MAP2K2 is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene.
UniGene ID: Hs.465627
HGNC ID: HGNC:6842