human LUM shRNA silencing AAV

Cat. No: shAAV-214676

Availability: 4-5 weeks

Name: AAV-h-LUM-shRNA

This is an AAV expressing shRNA for silencing of Human LUM.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: LUM
Gene Name: lumican
Gene ID: 4060
Gene Synonyms: LDC; SLRR2D
ORF Size: 1017 bp
RefSeq#: NM_002345
Gene Description: LUM encodes a member of the small leucine-rich proteoglycan (SLRP) family that includes decorin, biglycan, fibromodulin, keratocan, epiphycan, and osteoglycin. In these bifunctional molecules, the protein moiety binds collagen fibrils and the highly charged hydrophilic glycosaminoglycans regulate interfibrillar spacings. Lumican is the major keratan sulfate proteoglycan of the cornea but is also distributed in interstitial collagenous matrices throughout the body. Lumican may regulate collagen fibril organization and circumferential growth, corneal transparency, and epithelial cell migration and tissue repair.
UniGene ID: Hs.406475
HGNC ID: HGNC:6724