human LRP6 shRNA silencing AAV

Cat. No: shAAV-214507

Availability: 4-5 weeks

Name: AAV-h-LRP6-shRNA

This is an AAV expressing shRNA for silencing of Human LRP6.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: LRP6
Gene Name: LDL receptor related protein 6
Gene ID: 4040
Gene Synonyms: ADCAD2; STHAG7
ORF Size: 4842 bp
RefSeq#: NM_002336
Gene Description: LRP6 encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.
UniGene ID: Hs.658913
HGNC ID: HGNC:6698