human LRP5 shRNA silencing AAV

Cat. No: shAAV-214503

Availability: 4-5 weeks

Name: AAV-h-LRP5-shRNA

This is an AAV expressing shRNA for silencing of Human LRP5.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: LRP5
Gene Name: LDL receptor related protein 5
Gene ID: 4041
Gene Synonyms: BMND1; EVR1; EVR4; HBM; LR3; LRP-5; LRP7; OPPG; OPS; OPTA1; VBCH2
ORF Size: 4848 bp
RefSeq#: NM_002335
Gene Description: LRP5 encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative vitreoretinopathy.
UniGene ID: Hs.6347
HGNC ID: HGNC:6697