human LOXL2 shRNA silencing AAV

Cat. No: shAAV-214438

Availability: 6-8 weeks

Name: AAV-h-LOXL2-shRNA

This is an AAV expressing shRNA for silencing of Human LOXL2.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: LOXL2
Gene Name: lysyl oxidase like 2
Gene ID: 4017
Gene Synonyms: LOR2; WS9-14
ORF Size: 2325 bp
RefSeq#: NM_002318
Gene Description: LOXL2 encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family.
UniGene ID: Hs.661130
HGNC ID: HGNC:6666