human CCBP2 shRNA silencing AAV

Cat. No: shAAV-214392

Availability: 6-8 weeks

Name: AAV-h-CCBP2-shRNA

This is an AAV expressing shRNA for silencing of Human ACKR2.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: ACKR2
Gene Name: atypical chemokine receptor 2
Gene ID: 1238
Gene Synonyms: CCBP2; CCR10; CCR9; CMKBR9; D6; hD6
ORF Size: 1155 bp
RefSeq#: NM_001296
Gene Description: CCBP2 encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. CCBP2 is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific function remains unknown. CCBP2 is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes.
UniGene ID: Hs.146346
HGNC ID: HGNC:1565