human TBK1 shRNA silencing AAV

Cat. No: shAAV-214067

Availability: 4-5 weeks

Name: AAV-h-TBK1-shRNA

This is an AAV expressing shRNA for silencing of Human TBK1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: TBK1
Gene Name: TANK binding kinase 1
Gene ID: 29110
Gene Synonyms: FTDALS4; NAK; T2K
ORF Size: 2190 bp
RefSeq#: NM_013254
Gene Description: The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors.
UniGene ID: Hs.607889
HGNC ID: HGNC:11584