human LEPRE1 shRNA silencing AAV

Cat. No: shAAV-213835

Availability: 6-8 weeks

Name: AAV-h-LEPRE1-shRNA

This is an AAV expressing shRNA for silencing of Human P3H1.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: P3H1
Gene Name: prolyl 3-hydroxylase 1
Gene ID: 64175
Gene Synonyms: GROS1; LEPRE1; OI8
ORF Size: 2094 bp
RefSeq#: NM_022356
Gene Description: LEPRE1 encodes an enzyme that is a member of the collagen prolyl hydroxylase family. These enzymes are localized to the endoplasmic reticulum and their activity is required for proper collagen synthesis and assembly. Mutations in this gene are associated with osteogenesis imperfecta type VIII. Three alternatively spliced transcript variants encoding different isoforms have been described. Other variants may exist, but their biological validity has not been determined.
UniGene ID: Hs.437656
HGNC ID: HGNC:19316