human LATS2 shRNA silencing AAV

Cat. No: shAAV-213706

Availability: 4-5 weeks

Name: AAV-h-LATS2-shRNA

This is an AAV expressing shRNA for silencing of Human LATS2.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: LATS2
Gene Name: large tumor suppressor kinase 2
Gene ID: 26524
Gene Synonyms: KPM
ORF Size: 3264 bp
RefSeq#: NM_014572
Gene Description: LATS2 encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression.
UniGene ID: Hs.78960
HGNC ID: HGNC:6515