human KCNQ3 shRNA silencing AAV

Cat. No: shAAV-212773

Availability: 6-8 weeks

Name: AAV-h-KCNQ3-shRNA

This is an AAV expressing shRNA for silencing of Human KCNQ3.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: KCNQ3
Gene Name: potassium voltage-gated channel subfamily Q member 3
Gene ID: 3786
Gene Synonyms: BFNC2; EBN2; KV7.3
ORF Size: 2616 bp
RefSeq#: NM_004519
Gene Description: The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and one of two related proteins encoded by the KCNQ2 and KCNQ5 genes, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 2 (BFNC2), also known as epilepsy, benign neonatal type 2 (EBN2). Two variants encoding distinct isoforms have been found.
UniGene ID: Hs.374023
HGNC ID: HGNC:6297