human KCNN2 shRNA silencing AAV

Cat. No: shAAV-212766

Availability: 6-8 weeks

Name: AAV-h-KCNN2-shRNA

This is an AAV expressing shRNA for silencing of Human KCNN2.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: KCNN2
Gene Name: potassium calcium-activated channel subfamily N member 2
Gene ID: 3781
Gene Synonyms: hSK2; KCa2.2; SK2; SKCa 2; SKCA2
ORF Size: 1740 bp
RefSeq#: NM_021614
Gene Description: Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene is a member of the KCNN family of potassium channel genes. Two transcript variants encoding different isoforms have been found for this gene.
UniGene ID: Hs.98280
HGNC ID: HGNC:6291