human KCNA6 shRNA silencing AAV

Cat. No: shAAV-212659

Availability: 6-8 weeks

Name: AAV-h-KCNA6-shRNA

This is an AAV expressing shRNA for silencing of Human KCNA6.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: KCNA6
Gene Name: potassium voltage-gated channel subfamily A member 6
Gene ID: 3742
Gene Synonyms: HBK2; KV1.6; PPP1R96
ORF Size: 1590 bp
RefSeq#: NM_002235
Gene Description: Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class. The coding region of this gene is intronless, and the gene is clustered with genes KCNA1 and KCNA5 on chromosome 12.
UniGene ID: Hs.426162
HGNC ID: HGNC:6225