human JRK shRNA silencing AAV

Cat. No: shAAV-212594

Availability: 6-8 weeks

Name: AAV-h-JRK-shRNA

This is an AAV expressing shRNA for silencing of Human JRK.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: JRK
Gene Name: Jrk helix-turn-helix protein
Gene ID: 8629
Gene Synonyms: jerky; JH8
ORF Size: 1707 bp
RefSeq#: NM_003724
Gene Description: JRK is the human homolog of the mouse jerky gene. The encoded protein has similarity to several nuclear regulatory proteins, including centromere protein B, suggesting that it might function as a DNA-binding protein. Insertional inactivation of this gene in transgenic mice resulted in epileptic seizures. Childhood Absence Epilepsy (CAE) has been mapped to the same chromosomal location (8q24.3) as this gene, making this gene a strong candidate for CAE. Two transcript variants encoding different isoforms have been found for this gene.
UniGene ID: Hs.683465
HGNC ID: HGNC:6199