human ITGB3BP shRNA silencing AAV

Cat. No: shAAV-212510

Availability: 4-5 weeks

Name: AAV-h-ITGB3BP-shRNA

This is an AAV expressing shRNA for silencing of Human ITGB3BP.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: ITGB3BP
Gene Name: integrin subunit beta 3 binding protein
Gene ID: 23421
Gene Synonyms: CENP-R; CENPR; HSU37139; NRIF3; TAP20
ORF Size: 534 bp
RefSeq#: NM_014288
Gene Description: ITGB3BP encodes a transcriptional coregulator that binds to and enhances the activity of members of the nuclear receptor families, thyroid hormone receptors and retinoid X receptors. This protein also acts as a corepressor of NF-kappaB-dependent signaling. This protein induces apoptosis in breast cancer cells through a caspase 2-mediated signaling pathway. This protein is also a component of the centromere-specific histone H3 variant nucleosome associated complex (CENP-NAC) and may be involved in mitotic progression by recruiting the histone H3 variant CENP-A to the centromere. Alternate splicing results in multiple transcript variants.
UniGene ID: Hs.166539
HGNC ID: HGNC:6157