human ITGA2B shRNA silencing AAV

Cat. No: shAAV-212475

Availability: 4-5 weeks

Name: AAV-h-ITGA2B-shRNA

This is an AAV expressing shRNA for silencing of Human ITGA2B.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: ITGA2B
Gene Name: integrin subunit alpha 2b
Gene ID: 3674
Gene Synonyms: BDPLT16; BDPLT2; CD41; CD41B; GP2B; GPIIb; GT; GTA; HPA3; PPP1R93
ORF Size: 3120 bp
RefSeq#: NM_000419
Gene Description: ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.
UniGene ID: Hs.411312
HGNC ID: HGNC:6138