human IRF8 shRNA silencing AAV

Name
AAV-h-IRF8-shRNA

Cat No
shAAV-212413

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human IRF8.

shAAV-212413

AAV-h-IRF8-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human IRF8 (interferon regulatory factor 8). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

H-ICSBP; ICSBP; ICSBP1; IMD32A; IMD32B; IRF-8

Description (Vector)

Interferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced by viral infection.

Gene ID

3394

Gene Name (Vector)

interferon regulatory factor 8

Gene Symbol

IRF8

HGNC ID

HGNC:5358

ORF Size (aa)

1281

ORF Size (bp)

1281 bp

RefSeq ID

NM_002163

RefSeq Synonyms

NM_002163, BC126247,

Species

human

UniGene ID

Hs.137427

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.