human IMPDH2 shRNA silencing AAV

Cat. No: shAAV-212246

Availability: 4-5 weeks

Name: AAV-h-IMPDH2-shRNA

This is an AAV expressing shRNA for silencing of Human IMPDH2.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: IMPDH2
Gene Name: inosine monophosphate dehydrogenase 2
Gene ID: 3615
Gene Synonyms: IMPD2; IMPDH-II
ORF Size: 1545 bp
RefSeq#: NM_000884
Gene Description: IMPDH2 encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. IMPDH2 is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation.
UniGene ID: Hs.654400
HGNC ID: HGNC:6053