human IL27 shRNA silencing AAV

Cat. No: shAAV-212163

Availability: 6-8 weeks

Name: AAV-h-IL27-shRNA

This is an AAV expressing shRNA for silencing of Human IL27.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: IL27
Gene Name: interleukin 27
Gene ID: 246778
Gene Synonyms: IL-27; IL-27A; IL27A; IL27p28; IL30; p28
ORF Size: 732 bp
RefSeq#: NM_145659
Gene Description: IL27 is one of the subunits of a heterodimeric cytokine complex. This protein is related to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similar to interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but not memory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferon gamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by the class I cytokine receptor (WSX1/TCRR).
UniGene ID: Hs.528111
HGNC ID: HGNC:19157