human IL2 shRNA silencing AAV

Cat. No: shAAV-212119

Availability: 6-8 weeks

Name: AAV-h-IL2-shRNA

This is an AAV expressing shRNA for silencing of Human IL2.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: IL2
Gene Name: interleukin 2
Gene ID: 3558
Gene Synonyms: IL-2; lymphokine; TCGF
ORF Size: 462 bp
RefSeq#: NM_000586
Gene Description: IL2 is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli.
UniGene ID: Hs.89679
HGNC ID: HGNC:6001