human IGF1R shRNA silencing AAV

Cat. No: shAAV-211913

Availability: 4-5 weeks

Name: AAV-h-IGF1R-shRNA

This is an AAV expressing shRNA for silencing of Human IGF1R.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: IGF1R
Gene Name: insulin like growth factor 1 receptor
Gene ID: 3480
Gene Synonyms: CD221; IGFIR; IGFR; JTK13
ORF Size: 4101 bp
RefSeq#: NM_000875
Gene Description: This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival.
UniGene ID: Hs.714012
HGNC ID: HGNC:5465