human IDS shRNA silencing AAV

Cat. No: shAAV-211780

Availability: 4-5 weeks

Name: AAV-h-IDS-shRNA

This is an AAV expressing shRNA for silencing of Human IDS.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: IDS
Gene Name: iduronate 2-sulfatase
Gene ID: 3423
Gene Synonyms: MPS2; SIDS
ORF Size: 939 bp
RefSeq#: NM_000202
Gene Description: Iduronate-2-sulfatase is required for the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in this X-chromosome gene that result in enzymatic deficiency lead to the sex-linked Mucopolysaccharidosis Type II, also known as Hunter Syndrome. Iduronate-2-sulfatase has a strong sequence similarity with human arylsulfatases A, B, and C, and human glucosamine-6-sulfatase. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described.
UniGene ID: Hs.460960
HGNC ID: HGNC:5389