human HLCS shRNA silencing AAV

Cat. No: shAAV-211242

Availability: 4-5 weeks

Name: AAV-h-HLCS-shRNA

This is an AAV expressing shRNA for silencing of Human HLCS.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: HLCS
Gene Name: holocarboxylase synthetase
Gene ID: 3141
Gene Synonyms: HCS
ORF Size: 2181 bp
RefSeq#: NM_000411
Gene Description: HLCS encodes an enzyme that catalyzes the binding of biotin to carboxylases and histones. The protein plays an important role in gluconeogenesis, fatty acid synthesis and branched chain amino acid catabolism. Defects in this gene are the cause of holocarboxylase synthetase deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified.
UniGene ID: Hs.371350
HGNC ID: HGNC:4976