human HLA-DPA1 shRNA silencing AAV

Cat. No: shAAV-211216

Availability: 4-5 weeks

Name: AAV-h-HLA-DPA1-shRNA

This is an AAV expressing shRNA for silencing of Human HLA-DPA1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: HLA-DPA1
Gene Name: major histocompatibility complex, class II, DP alpha 1
Gene ID: 3113
Gene Synonyms: DP(W3); DP(W4); HLA-DP1A; HLADP; HLASB; PLT1
ORF Size: 783 bp
RefSeq#: NM_033554
Gene Description: HLA-DPA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta (DPB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.
UniGene ID: Hs.347270
HGNC ID: HGNC:4938