human HIP1 shRNA silencing AAV

Cat. No: shAAV-211038

Availability: 4-5 weeks

Name: AAV-h-HIP1-shRNA

This is an AAV expressing shRNA for silencing of Human HIP1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: HIP1
Gene Name: huntingtin interacting protein 1
Gene ID: 3092
Gene Synonyms: HIP-I; ILWEQ; SHON; SHONbeta; SHONgamma
ORF Size: 3114 bp
RefSeq#: NM_005338
Gene Description: The product of this gene is a membrane-associated protein that colocalizes with huntingtin. This protein has similarities to cytoskeleton proteins and its interaction with huntingtin is thought to play a functional role in the cell filament network. Loss of normal huntingtin-HIP1 interaction in Huntington disease may contribute to a defect in membrane-cytoskeletal integrity in the brain. This gene could help in the understanding of the normal function of huntingtin and also the pathogenesis of Huntington disease. It also has been implicated in the pathogenesis of hematopoietic malignancies. Two transcript variants encoding different isoforms have been found for this gene.
UniGene ID: Hs.619089
HGNC ID: HGNC:4913