human HERC3 shRNA silencing AAV

Cat. No: shAAV-210952

Availability: 6-8 weeks

Name: AAV-h-HERC3-shRNA

This is an AAV expressing shRNA for silencing of Human HERC3.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: HERC3
Gene Name: HECT and RLD domain containing E3 ubiquitin protein ligase 3
Gene ID: 8916
ORF Size: 3153 bp
RefSeq#: NM_014606
Gene Description: HERC3 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins (Hochrainer et al., 2005 (PubMed 15676274)).(supplied by OMIM, Mar 2008)
UniGene ID: Hs.35804
HGNC ID: HGNC:4876