human HDAC5 shRNA silencing AAV

Cat. No: shAAV-210890

Availability: 4-5 weeks

Name: AAV-h-HDAC5-shRNA

This is an AAV expressing shRNA for silencing of Human HDAC5.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: HDAC5
Gene Name: histone deacetylase 5
Gene ID: 10014
Gene Synonyms: HD5; NY-CO-9
ORF Size: 3369 bp
RefSeq#: NM_005474
Gene Description: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene.
UniGene ID: Hs.438782
HGNC ID: HGNC:14068