human HDAC4 shRNA silencing AAV

Cat. No: shAAV-210889

Availability: Immediate

Name: AAV-h-HDAC4-shRNA

This is an AAV expressing shRNA for silencing of Human HDAC4.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: HDAC4
Gene Name: histone deacetylase 4
Gene ID: 9759
Gene Synonyms: AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A; HDACA
ORF Size: 2919 bp
RefSeq#: NM_006037
Gene Description: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3.
UniGene ID: Hs.688314
HGNC ID: HGNC:14063