human GYPB shRNA silencing AAV

Cat. No: shAAV-210705

Availability: 6-8 weeks

Name: AAV-h-GYPB-shRNA

This is an AAV expressing shRNA for silencing of Human GYPB.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: GYPB
Gene Name: glycophorin B (MNS blood group)
Gene ID: 2994
Gene Synonyms: CD235b; GPB; GYP; MNS; PAS-3; SS
ORF Size: 276 bp
RefSeq#: NM_002100
Gene Description: Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. GYPB gene consists of 5 exons and has 97% sequence homology with GYPA from the 5' UTR to the coding sequence encoding the first 45 amino acids. In addition to the M or N and S or s antigens, that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta; also, Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene recombinations between GYPA and GYPB.
UniGene ID: Hs.654368
HGNC ID: HGNC:4703