human GRIN2B shRNA silencing AAV

Cat. No: shAAV-210524

Availability: 6-8 weeks

Name: AAV-h-GRIN2B-shRNA

This is an AAV expressing shRNA for silencing of Human GRIN2B.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: GRIN2B
Gene Name: glutamate ionotropic receptor NMDA type subunit 2B
Gene ID: 2904
Gene Synonyms: EIEE27; GluN2B; hNR3; MRD6; NMDAR2B; NR2B
ORF Size: 4455 bp
RefSeq#: NM_000834
Gene Description: N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain.
UniGene ID: Hs.654430
HGNC ID: HGNC:4586