human GRIK1 shRNA silencing AAV

Cat. No: shAAV-210514

Availability: 6-8 weeks

Name: AAV-h-GRIK1-shRNA

This is an AAV expressing shRNA for silencing of Human GRIK1.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: GRIK1
Gene Name: glutamate ionotropic receptor kainate type subunit 1
Gene ID: 2897
Gene Synonyms: EAA3; EEA3; GLR5; GluK1; gluR-5; GLUR5
ORF Size: 2718 bp
RefSeq#: NM_000830
Gene Description: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to alter the properties of ion flow. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene.
UniGene ID: Hs.706747
HGNC ID: HGNC:4579