human GRB2 shRNA silencing AAV

Cat. No: shAAV-210489

Availability: 4-5 weeks

Name: AAV-h-GRB2-shRNA

This is an AAV expressing shRNA for silencing of Human GRB2.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: GRB2
Gene Name: growth factor receptor bound protein 2
Gene ID: 2885
Gene Synonyms: ASH; EGFRBP-GRB2; Grb3-3; MST084; MSTP084; NCKAP2
ORF Size: 654 bp
RefSeq#: NM_002086
Gene Description: GRB2 binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.
UniGene ID: Hs.444356
HGNC ID: HGNC:4566