human GPI shRNA silencing AAV

Cat. No: shAAV-210233

Availability: 4-5 weeks

Name: AAV-h-GPI-shRNA

This is an AAV expressing shRNA for silencing of Human GPI.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: GPI
Gene Name: glucose-6-phosphate isomerase
Gene ID: 2821
Gene Synonyms: AMF; GNPI; NLK; PGI; PHI; SA-36; SA36
ORF Size: 1677 bp
RefSeq#: NM_000175
Gene Description: GPI belongs to the GPI family whose members encode multifunctional phosphoglucose isomerase proteins involved in energy pathways. The protein encoded by this gene is a dimeric enzyme that catalyzes the reversible isomerization of glucose-6-phosphate and fructose-6-phosphate. The protein functions in different capacities inside and outside the cell. In the cytoplasm, the gene product is involved in glycolysis and gluconeogenesis, while outside the cell it functions as a neurotrophic factor for spinal and sensory neurons. Defects in this gene are the cause of nonspherocytic hemolytic anemia and a severe enzyme deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment.
UniGene ID: Hs.466471
HGNC ID: HGNC:4458