human GPBAR1 shRNA silencing AAV

Cat. No: shAAV-210213

Availability: 6-8 weeks

Name: AAV-h-GPBAR1-shRNA

This is an AAV expressing shRNA for silencing of Human GPBAR1.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: GPBAR1
Gene Name: G protein-coupled bile acid receptor 1
Gene ID: 151306
Gene Synonyms: BG37; GPCR19; GPR131; M-BAR; TGR5
ORF Size: 993 bp
RefSeq#: NM_170699
Gene Description: GPBAR1 encodes a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in multiple transcript variants encoding the same protein.
UniGene ID: Hs.160954
HGNC ID: HGNC:19680