human GP6 shRNA silencing AAV

Cat. No: shAAV-210191

Availability: 6-8 weeks

Name: AAV-h-GP6-shRNA

This is an AAV expressing shRNA for silencing of Human GP6.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: GP6
Gene Name: glycoprotein VI platelet
Gene ID: 51206
Gene Synonyms: BDPLT11; GPIV; GPVI
ORF Size: 1020 bp
RefSeq#: NM_016363
Gene Description: GP6 encodes a platelet membrane glycoprotein of the immunoglobulin superfamily. The encoded protein is a receptor for collagen and plays a critical role in collagen-induced platelet aggregation and thrombus formation. The encoded protein forms a complex with the Fc receptor gamma-chain that initiates the platelet activation signaling cascade upon collagen binding. Mutations in this gene are a cause of platelet-type bleeding disorder-11 (BDPLT11). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
UniGene ID: Hs.661752
HGNC ID: HGNC:14388