human GNS shRNA silencing AAV

Cat. No: shAAV-210146

Availability: 4-5 weeks

Name: AAV-h-GNS-shRNA

This is an AAV expressing shRNA for silencing of Human GNS.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: GNS
Gene Name: glucosamine (N-acetyl)-6-sulfatase
Gene ID: 2799
Gene Synonyms: G6S
ORF Size: 1659 bp
RefSeq#: NM_002076
Gene Description: The product of this gene is a lysosomal enzyme found in all cells. It is involved in the catabolism of heparin, heparan sulphate, and keratan sulphate. Deficiency of this enzyme results in the accumulation of undegraded substrate and the lysosomal storage disorder mucopolysaccharidosis type IIID (Sanfilippo D syndrome). Mucopolysaccharidosis type IIID is the least common of the four subtypes of Sanfilippo syndrome.
UniGene ID: Hs.334534
HGNC ID: HGNC:4422