human GLUD1 shRNA silencing AAV

Cat. No: shAAV-210018

Availability: 4-5 weeks

Name: AAV-h-GLUD1-shRNA

This is an AAV expressing shRNA for silencing of Human GLUD1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: GLUD1
Gene Name: glutamate dehydrogenase 1
Gene ID: 2746
Gene Synonyms: GDH; GDH1; GLUD
ORF Size: 1677 bp
RefSeq#: NM_005271
Gene Description: GLUD1 encodes glutamate dehydrogenase protein; a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This enzyme has an important role in regulating amino acid induced insulin secretion and activating mutations in this gene are a common cause of congenital hyperinsulinism. This enzyme is allosterically activated by ADP and inhibited by GTP and ATP. The related glutamate dehydrogenase 2 gene on the human X-chromosome originated from this gene via retrotransposition and encodes a soluble form of glutamate dehydrogenase. Multiple pseudogenes of this gene are present in humans.
UniGene ID: Hs.500409
HGNC ID: HGNC:4335